Sample preparation is critical in forensic toxicology to ensure the accuracy and precision of analysis. Blood, urine, vitreous humor, liver, and stomach contents are commonly analyzed in postmortem toxicology. Each of these samples must be collected, labeled, and stored according to strict protocols to avoid contamination. Blood, urine, hair, and saliva are typically collected in cases involving drug or alcohol analysis. Biological samples should be preserved in a controlled environment, often at low temperatures, to prevent degradation. Use preservatives such as EDTA or sodium fluoride in blood samples to prevent bacterial growth and enzymatic breakdown of substances.

Sample Preparation Techniques

Protein Precipitation: Using solvents such as acetonitrile or methanol to precipitate proteins, removing them from the sample.

Liquid-Liquid Extraction: Involves separating compounds based on their solubility in different solvents. It is useful for isolating drugs or toxins from complex biological matrices.

Solid-Phase Extraction (SPE): SPE can be used for the extraction and clean-up of specific drugs from biological fluids.

Derivatization: In some cases, chemical derivatization is necessary to make analytes more detectable by mass spectrometry.

We prepare best procedures proper to your laboratory needs and all requirements for every stage of all sample preparation techniques ready for analysis in your analytical instruments